RESEARCH STUDIES
Over a decade of investment in science

Since 2010, we’ve set out to formulate the most comprehensive and effective Foundational Nutrition supplement.

Our driving belief: High-quality ingredients combined with healthy gut function could improve the body’s ability to absorb and actually use essential nutrients.

Our in-house team of doctors, scientists, and researchers worked with third-party experts to conduct a set of scientific studies and further validate the benefits of AG1.

01 — THE SHIME STUDY RESULTS
SHIME study
(Simulator of the Human Intestinal Microbial Ecosystem) A simulation of the human gastrointestinal tract, used to study the effects of AG1 on the gut in a controlled, highly reliable laboratory environment.

In a set of in vitro studies simulating the human gastrointestinal tract, AG1 was shown to support a healthy gut.*

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more minerals available for absorption vs. a multivitamin tablet‡

WHY THIS MATTERS
Adequate nutrient levels are needed to deliver their intended benefits. The more accessible a nutrient is to the digestive tract, the easier it is for absorption.*

‡In an in-vitro study that compared AG1 powder to a multivitamin tablet using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to be more digestible than the multivitamin tablet.

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increase in beneficial bacteria vs. control‡

WHY THIS MATTERS
Healthy bacteria are digestive allies that help break down food and support functions of the gut required to aid bloating and metabolism.*

‡In an in-vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to improve indicators of gut health.

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increase in short-chain fatty acid production vs. control‡

WHY THIS MATTERS
SCFAs are the superheroes of the gut: providing energy to digestive cells, helping keep the gut lining healthy, and supporting the immune system.*

‡In an in-vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to improve indicators of gut health.

“We intentionally designed AG1 to deliver a diverse spectrum of essential daily nutrients with pre and probiotics to support the gut, in a powder form that’s easier for your body to digest than a tablet.”*

Dr. Ralph Esposito ND, LAc — Functional Medicine, Chief Science & Nutrition Officer

02 — SINGLE-ARM STUDY RESULTS
Single-arm study
A study conducted with 35 healthy adults ages 25-48. We measured how participants reported feeling and behaving in different increments over the course of 90 days, and validated the data with a third-party clinical research organization to mitigate bias.

In a single-arm study that assessed the self-perceived efficacy of AG1, participants reported feeling positive impacts on stress, digestion, and energy.*

AT 30 DAYS†

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noticed less gas & bloating

AT 90 DAYS†

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noticed less cravings during the day
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WHY THIS MATTERS
Internal changes aren't always felt. By giving your body the routine nutrients it needs, you’re able to experience benefits that build each day.*

†In a single-arm study conducted on 35 healthy adults ages 25-48 assessing the self-perceived efficacy of AG1 over 90 days.

Our Team & Findings

Our research team

To contribute to the emerging body of research on foundational nutrition and to keep AG1 at the forefront of it, we rely on an in-house team of doctors, scientists, and researchers dedicated to bringing you the highest quality supplement.

Peer-reviewed research

In addition to sharing our results, we collaborate with other experts and researchers in the scientific community to publish research in peer-reviewed scientific journals, helping to lead the discourse on the complex and crucial role nutrition plays in overall health.

NUTRIENTS

Foundational Nutrition: Implications for Human Health

Human nutrition, and what can be considered “ideal” nutrition, is a complex, multi-faceted topic which many researchers and practitioners deliberate. While some attest that basic human nutrition is relatively understood, it is undeniable that a global nutritional problem persists.

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FRONTIERS

Nutrient synergy: definition, evidence, and future directions

Nutrient synergy refers to the concept that the combined effects of two or more nutrients working together have a greater physiological impact on the body than when each nutrient is consumed individually.

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NUTRACEUTICALS

The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®

Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.

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APPLIED BIOSCIENCE

AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract

While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements, which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.

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CURRENT ISSUES IN MOLECULAR BIOLOGY

AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal Microbial Ecosystem® Model

Considering previous experimental data on AG1 and the growing evidence that various phytochemicals can act as prebiotics, the primary objective of the current experiment was to detail the specific effects of AG1 on gut microbial community composition by observing changes in community structure and function.

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One scoop. Every morning. For life.

One scoop. Every morning. For life.

FAQs

What is a SHIME model?

The SHIME model, which stands for Simulator of the Human Intestinal Microbial Ecosystem, is an in vitro model used in research to study the human gastrointestinal tract. It consists of a series of interconnected sections, called bioreactors, that mimic the physiological and biological conditions found in the human gut, including the stomach, small intestine, and colon.

Why did you start with a SHIME study?

What is a single-arm study?

How do you validate your research data on AG1?

What measures do you take to ensure the quality of AG1?